Original article / research
Year :
2024 |
Month :
April
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Volume :
13 |
Issue :
2 |
Page :
PO27 - PO30 |
Full Version
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Evaluation of Serum β2-Microglobulin Levels in Histologically Diagnosed Oral Squamous Cell Carcinoma Patients
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Arushi Agrawal, Pooja Agarwal, Nupur Kaushik, Yatendra Mohan, Shikha Prakash, Akhil Pratap Singh, Ankur Agarwal 1. Junior Resident, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
2. Professor and Head, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
3. Senior Resident, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
4. Assistant Professor, Department of Transfusion Medicine, S.N. Medical College, Agra, Uttar Pradesh, India.
5. Assistant Professor, Department of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India.
6. Assistant Professor, Department of Ear, Nose and Throat, S.N. Medical College, Agra, Uttar Pradesh, India.
7. Senior Resident, Department of Surgery, GIMS, Greater Noida, Uttar Pradesh, India.
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Correspondence
Address :
Arushi Agrawal, Pooja Agarwal, Nupur Kaushik, Yatendra Mohan, Shikha Prakash, Akhil Pratap Singh, Ankur Agarwal, Dr. Pooja Agarwal,
79, Gandhi Nager, Bypass Road, Agra-282003, Uttar Pradesh, India.
E-mail: drpooja.agarwal@gmail.com
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| ABSTRACT | | : Introduction: Oral cancer presents challenging and unresolved problems for the human population, accounting for as much as 30-40% of all carcinomas in India. The current research focuses on the use of the tumour marker β2-microglobulin as a surrogate marker in patients with Oral Squamous Cell Carcinoma (OSCC) for early detection of cancer.
Aim: To evaluate the level of serum β2-microglobulin in histologically diagnosed OSCC patients and compare it with age- and sex-matched healthy controls.
Materials and Methods: This was a cross-sectional study conducted in the Department of Pathology at SN Medical College, Agra, over a period of one year and six months. The study included 50 histologically diagnosed OSCC cases and 40 age- and sex-matched healthy controls. Blood samples were taken from the healthy controls and OSCC patients, and the level of serum β2-microglobulin was measured using Enzyme Linked Immunosorbent Assay (ELISA). Statistical analysis was conducted using the Statistical Package for Social Sciences (SPSS) version 11. Z test and ANOVA test were used to compare various parameters. A p-value of <0.05 was considered significant.
Results: In the 50 cases of OSCC, the mean±SD of serum β2-microglobulin was 2.99±0.85 μg/mL, while in the healthy controls, it was 1.30±0.10 μg/mL, with a p-value <0.001, which was statistically significant. The mean±SD of serum β2-microglobulin in cases of Well Differentiated Squamous Cell Carcinoma (WDSCC) was 2.40±1.59 μg/mL, whereas it was 3.09±1.52 μg/mL in Moderately Differentiated Squamous Cell Carcinoma (MDSCC) and 3.46±0.03 μg/mL in Poorly Differentiated Squamous Cell Carcinoma (PDSCC), with a p-value of <0.05, which was statistically significant. Increased levels of serum β2-microglobulin were observed among all cases of OSCC. Loss of differentiation in Squamous Cell Carcinoma (SCC) was associated with an increase in levels of serum β2-microglobulin.
Conclusion: Due to its minimally invasive nature and quick availability of results, serum β2-microglobulin can be used for diagnosis of OSCC. Therefore, it is recommended to monitor levels of serum β2-microglobulin in patients with OSCC.
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Keywords
: ELISA, Oral cancer, Surrogate marker for oral cancer |
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DOI and Others
: DOI: 10.7860/NJLM/2024/66217.2837
Date of Submission: Jun 23, 2023
Date of Peer Review: Sep 11, 2023
Date of Acceptance: Nov 08, 2023
Date of Publishing: Apr 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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